Bioinformatics tools for disordered proteins

Predictor

Principle

IUPred estimated interaction energy
GlobPlot single AA propensity
DISOPRED2 SVM + NN for smoothing
PONDR® VSL2 SVM
PONDR-FIT Meta server based on NN
Predisorder 1-D recursive NN with profiles
CSpritz SVM with non-linear kernel
FoldIndex© AA propensities
RONN bio-basis function neural network
DRIP-PRED self-organizing maps
DisPSSM (iPDA) two-stage classifier of Radial Basis Function Networks (RBFN)
POODLE (S, L, W, I) SVM with physicochemical properties
UCON Low contact density
MD Meta-predictor
PrDOS SVM + homology
OnD-CRF Conditional random fields
DISOclust 3D structural models

Databases:

  • Disprot: Database of experimentally verified disordered proteins
  • ELM: Database of eukarotic linear motifs
  • PDB: 3D Structural database of proteins
  • BMRB: Biological Magnetic Resonance Data Bank

Additional Tools and Resources: