IDPbyNMR workshop "Looking at intrinsically disordered proteins through NMR: challenges and perspectives"
June 30th, Creta Maris Hotel, Hersonissos, Crete, Greece

The EUROMAR in Crete provides an ideal opportunity to discuss about how NMR can contribute to the study of intrinsically disordered proteins that thanks to their high extent of disorder and flexibility are challenging well accepted concepts in structural biology. In the spirit of the IDPbyNMR Marie Curie ITN, the PhD students and post-docs will have an active role in the discussion by presenting their results as well as the challenges they are encountering in their research.



10.00-10.10 Roberta Pierattelli, CERM, University of Florence, Italy
Opening and introduction to the workshop
10.10-10.30 Sergio Gil, Bruker BioSpin AG, Fällanden, Switzerland
Evaluating the contributions to 1H longitudinal relaxation enhancement through 13C detected experiments for the investigation of intrinsically disordered proteins
10.30-10.50 Tomáš Hošek, CERM, University of Florence, Italy
NMR studies of IDPs at near physiological conditions: exploiting fast hydrogen exchange to boost experimental sensitivity
10.50-11.10 Anna Zawadzka-Kazimierczuk, University of Warsaw, Poland
An optimal set of multidimensional experiments for resonance assignment of intrinsically disordered proteins
11.10-11.30 Jiří Nováček, Masaryk University, Brno, Czech Republic
Transient local conformations of a 49kDa intrinsically disordered protein determined by NMR
11.30-11.50 Coffe break
11. 50-12.10 Guillaume Communie, IBS and UVHCI, Grenoble, France
Order and disorder in the replication machinery of Paramyxoviruses
12.10-12.30 Pryanka Joshi, University of Cambridge, UK
Towards a fragment based drug design strategy to design small molecules as inhibitors of Abeta aggregation
12.30-12.50 François Theillet, FMP Berlin, Germany
In-cell dynamics, interactions and structural features of the human amyloidogenic protein alpha-synuclein
12.50-13.20 Miquel Pons, University of Barcelona, Spain
Round Table and Brainstorming on NMR and IDPs
13.20-13.30 Isabella C. Felli, CERM, University of Florence, Italy
Closing remarks
13.30-14.00 Lunch snacks